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A: We do not all need to avoid gluten - a protein in wheat, rye and barley. People with celiac disease must avoid gluten, because for them any amount of gluten damages the intestine. They often experience digestive problems from gluten and even small amounts of gluten can increase their risk of health problems over time. Recent research shows that some genetically susceptible individuals who do not have celiac disease may have an abnormal immune response to gluten and also digestive problems.This "non-gluten-sensitive celiac disease" may be linked to irritable bowel syndrome, rheumatoid arthritis, certain skin conditions, migraines and more. However, for people who do not have this gluten sensitivity, avoiding gluten no benefit.